NFKB1 and breast cancer: This inhibitory cross-talk can be appreciated from the fact that an increase in both NF-κB DNA-binding activity (Nakshatri et al, 1997; Pratt et al, 2003) and expression of NF-κB target genes like IL8 (Freund et al, 2004) coincides with a shift from oestrogen dependence to oestrogen independence in breast cancer.