Out of 11 ER target genes, four ER target genes showed significant differences between tumours with and without transcriptionally active NF-κB: GATA3 (P=0.001), MYB (P=0.004), HSD17β4 (P=0.030) and STARD10 (P=0.013). The gene discussed is HSD17B4; the disease is neoplasm.