ERBB2 and breast neoplasm: It should be noted that, the increased activation of NF-κB is not exclusively linked to the IBC phenotype, but more generally to ER-independent breast tumours, which have a more frequent EGFR and/or ErbB2 amplification, hence breast tumours belong to the Basal-like and ErbB2-overexpressing cell-of-origin subtypes respectively.