TMPRSS2 and prostate carcinoma: The importance of genomic rearrangements in prostate cancer was emphasised by the discovery of recurrent translocations in 40–60% of prostate carcinoma and in 21% of the presumed premalignant lesion, high-grade prostatic intraepithelial neoplasia (HPIN), involving the TMPRSS2 gene with members of the erythroblast transformation-specific (ETS) transcription factor family (Tomlins et al, 2005, 2006; Ahlers and Figg, 2006; Cerveira et al, 2006; Perner et al, 2006; Soller et al, 2006; Wang et al, 2006; Yoshimoto et al, 2006b).