However, the majority of studies that have investigated the role of BRCA2 mutations in hereditary prostate cancer (HPC) families, which usually include men diagnosed with prostate cancer at younger ages, have reported no disease-associated mutations (Wilkens et al, 1999; Gayther et al, 2000; Sinclair et al, 2000; Agalliu et al, 2007). This evidence concerns the gene BRCA2 and prostate carcinoma.