However, some patients with grade 3/pT2 M1 tumor had a good response to IFN-α (M1-IFNa(+)/CR-PR), while an other patient with a grade 1/pT1 M1 tumor presented with lung metastases and had resistant disease (M1-IFNa(+)/PD) (Table 1). The gene discussed is IFNA1; the disease is neoplasm.