Recently, Motzer et al. [17] identified five prognostic factors (Karnofsky performance status, time from diagnosis of RCC to treatment with IFN-α, serum lactate dehydrogenese, corrected serum calcium, and hemoglobin) that correlated with overall survival in patients with metastatic RCC treated with IFN-α as their initial systemic therapy. Here, IFNA1 is linked to renal cell carcinoma.