A recently published investigation has also indicated that NF-κB activation, proinflammatory cytokines levels, ICAM-1 mRNA expression and myeloperoxidase activity were not affected by modified fluid gelatin in a polymicrobial sepsis model [17] – whereas, like other artificial colloids, gelatin impairs firm leukocyte adhesion to the endothelium in vitro [23], and applied in the priming fluid gelatin reduces the contact activation of complement cascades by binding to fragment Ba [24]. The gene discussed is ICAM1; the disease is Sepsis.