Although IFNγ effects mediated by TNFRI would be inhibited by the presence of p21 in the cell cytoplasm, the p21 location in in situ carcinomas would be capable to inhibit the apoptotic pathway of TNFRI at ASK-1 level [31], and thus, to prevent the IFNγ function as cell cycle inhibitor. The gene discussed is TNFRSF1A; the disease is carcinoma.