Interestingly in healing gastric ulcers we confirmed that sangre de grado therapy reduces the expression of inducible nitric oxide synthase (iNOS) in the ulcer bed, along with IL-1β, IL-6, TNFα and COX2, so it may limit the tissue burden of peroxynitrite by molecular quenching (NORAC test) and by limiting the production of nitric oxide, peroxynitrite's molecular parent, by suppressing iNOS gene expression [3]. Here, NOS2 is linked to ulcer disease.