ERBB2 and neoplasm: We further investigated the site-specific phosphorylation of Hsp27 at Ser78, Ser82 and Ser15, with the aim of elucidating the regulatory role of HER-2/neu-p38MAPK in Hsp27 phosphorylation and the correlations of their respective pSer profiles with two adverse criteria, HER-2/neu and lymph node positivity, associated with tumor progression and poor prognosis.