CBP/p300 are universal transcription coactivators with HAT activity [50,51] that participate in multiple transcriptional events mediated by viral oncoproteins, hematopoiesis-related transcription factors, tumor suppressors, and nuclear receptors through the regulation of histone acetylation and interaction with the basal transcriptional machinery [52-55]. The gene discussed is TMPRSS11D; the disease is neoplasm.