To clinically validate p75NTR's role in glioma migration and invasion, and demonstrate its relevance in malignant glioma patient specimens, we analyzed the expression of p75NTR in a panel of surgically resected tumor specimens and normal human brain using immunohistochemical staining (Figure 6A), RT-PCR, and Western blot (Figure 6B). This evidence concerns the gene NGFR and central nervous system cancer.