Likewise, tissue factor pathway inhibitor 2 (TFPI2), an anticoagulant, was strongly up-regulated during infection in all animals (averaging ∼20-fold), as well as PLSCR1, SERPINE1 (PAI1), and THBS1, all genes involved in pro-coagulation and platelet activation, were induced. The gene discussed is THBS1; the disease is infection.