Notable among the novel proteins identified by HPLC-MS/MS in secretory vesicles is LGMD2B, the membrane protein encoded by the gene that is mutated in two human muscular dystrophies, limb-girdle muscular dystrophy type 2B (LGMD2B) [55,56] and Miyoshi myopathy (MM) [57]. This evidence concerns the gene DYSF and Miyoshi myopathy.