Immunostainable TGF-β1 has been detected in the malignant epithelial cells in the majority of our investigated cases of colon carcinomas and expression was shown to be higher in low-grade tumours, as shown recently [34], whereas we found no correlation to lymph node metastases, tumour stage or survival, although there was a non-significant trend towards lower TGF-β1 expression in tumours with regional lymph node metastases. The gene discussed is TGFB1; the disease is colon carcinoma.