On multivariate analysis using Cox regression analysis besides vessel infiltration and lymph node status expression of TGF-β-R2 in the stroma (RR 2.2, 95%CI 1.2–3.8, p = 0.007, table 3) was an independent prognostic factor for cancer-related survival as reflected in Kaplan-Meier survival curve (see Fig. 2). The gene discussed is TGFBR2; the disease is cancer.