TNFα has been linked to IVD herniation and nerve irritation by a number of studies and the outcome of recent experiments using TNFα inhibitors has implicated this cytokine as an important mediator in LBP [15-20], whilst IL-1 has been shown to be directly involved in the decreased matrix synthesis and increased matrix degradation associated with IVD degeneration [12]. This evidence concerns the gene IL1A and Low back pain.