TNFα has been linked to IVD herniation and nerve irritation by a number of studies and the outcome of recent experiments using TNFα inhibitors has implicated this cytokine as an important mediator in LBP [15-20], whilst IL-1 has been shown to be directly involved in the decreased matrix synthesis and increased matrix degradation associated with IVD degeneration [12]. The gene discussed is IL1B; the disease is Low back pain.