More recently it has been reported that, in human MKN7 gastric cancer cells, HRGβ1 can also circumvent the antiproliferative action of the selective EGFR-TKI CGP59326 through promotion of erbB3/erbB2 heterodimerization and activation of the PI3K signalling pathway [44]. The gene discussed is ERBB3; the disease is gastric cancer.