EGFR and cancer: Combination therapy targeting HRGβ1 signalling alongside EGFR blockade can enhance the effectiveness of agents such as gefitinib on growth and invasion; however, the findings with trastuzumab and gefitinib in combination, where the minimal benefit of growth inhibition is offset by enhanced invasive capacity, suggest that rather than simply focusing on cell growth we should also consider other properties of the cancer phenotype if we are to fully understand the impact of these therapies on the cancer cell.