BRCA2 and leukemia: FANCD1 is the same as BRCA2 and a FANCD1/BRCA2 biallelic defect associates with leukemias that are much more likely to be myeloid than leukemias that develop in those with normal FANCD1/BRCA2. Myeloid leukemias have increased activity of the non-homologous end joining pathway, the less specific alternative to the BRCA pathway.