LG2 markers include 190 genes, among which are many oncogenes, (BCL2 (down, breast cancer poor prognosis marker), RAD51 (up), EGFR (up), RUNX3 (up), BCL9 (down) and VAV3 (down) and tumor suppressor gene NME1 (up). The gene discussed is BCL2; the disease is breast cancer.