Assuming mPR downregulates bcl-2, but not as strongly as PRA upregulates bcl-2, then in the absence of RU-486, P would have resulted in an increase in bcl-2 and therefore an increased incidence of BC due to the decrease in RD, whereas in the presence of RU-486, P would have resulted in a decrease in bcl-2 and therefore a decreased incidence of BC due to the increase in RD, which what was in fact observed. Here, BCL2 is linked to breast cancer.