IRF3 and infection: IRF-3−/− animals had significantly higher mean viral burdens at day 4 after infection in brain (107.6 PFU/g for IRF-3−/− and 105.7 PFU/g for wild-type, p = 0.02) and spinal cord (105.7 PFU/g for IRF-3−/− and 104.0 PFU/g for wild-type, p = 0.008).