TLR4 KO mice demonstrated higher bacterial loads only in spleen (p < 0.001) and blood (p < 0.05) at 24 h after infection; however, at later time points bacterial burdens did not differ significantly in TLR4 KO and WT mice in all body compartments except for the spleen at 72 h, revealing modestly fewer B. pseudomallei CFU in TLR4 KO mice (p < 0.001). Here, TLR4 is linked to infection.