TNF and neoplasm: The following model might explain our observations: (1) MALP-2 induces local inflammation; (2) surgery and local TNF release by MALP-2 activated monocytes/macrophages and cause tumour destruction; (3) leucocytes, including NK cells are directed to the injection site by the release of chemokines; (4) anergic DC are activated by MALP-2 to mature (Weigt et al, 2003).