EGFR is found to be overexpressed in more than 80% of head and neck cancers, activated by amplification and/or mutation in approximately 50% of gliomas, activated by mutation in about 10–15% of non-small cell lung cancers (NSCLC) in the west, and 30–50% of NSCLCs in Asia (Frederick et al, 2000; Riely et al, 2006). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.