ABCB1 and small cell lung carcinoma: In patient samples, good correlations have been reported between increased ABCB1 expression, lack of response to chemotherapy, and shorter survival (Holzmayer et al, 1992; Poupon et al, 1993; Savaraj et al, 1997), suggesting that ABCB1 gene expression may play a significant role in drug resistance in SCLC.