In addition to the nervous system, expression of the NrCAM gene (chromosome 7q31.1–q31.2) has also been demonstrated in a variety of healthy or neoplastic tissues and cell lines including pancreatic cancer, melanoma, renal and colon carcinoma, adrenal gland, placenta, thyroid, and testis (Wang et al, 1998; Dhodapkar et al, 2001; Conacci-Sorrell et al, 2002a). The gene discussed is NRCAM; the disease is melanoma.