Several lines of evidence indicate that expression of NrCAM and other members of the L1-CAM family might be important in the biological behaviour of human tumours (Wang et al, 1998; Dhodapkar et al, 2001; Fogel et al, 2003; Allory et al, 2005; Euer et al, 2005). The gene discussed is NRCAM; the disease is neoplasm.