The IL-6 −174G allele has been associated with susceptibility to systemic-onset juvenile RA in both a large case–control study (19) and a family-based association study (20) but not with susceptibility to RA (21), although it has been associated with a greater inflammation load in RA as assessed by modified Disease Activity Scores as measured in 28 joints (22,23). The gene discussed is IL6; the disease is rheumatoid arthritis.