ERBB2 and breast carcinoma: Our results demonstrated a significant correlation of the mean percentage of cells with structural centrosome amplification with HER2/neu overexpression (P < 0.05) and with negative ER status (P < 0.05), and demonstrated a borderline significant association between the mean percentage of cells with structural centrosome amplification and negative PR status (P = 0.056) in breast carcinomas.