SELPLG and malignant colon neoplasm: The aims of this study were to clone and overexpress the linoleic acid isomerase capable of producing t10, c12 CLA from P. acnes (Hornung et al., 2005) in Lactococcus lactis and Escherichia coli, and to investigate the anti-proliferative activity of the generated t10, c12 CLA using the human SW480 colon cancer cell line.