SELPLG and hepatocellular carcinoma: Yamasaki et al. (2002) have demonstrated a decrease in viable cell numbers of normal rat RLN-10 hepatocytes by the t10, c12 CLA isomer only at 25 μM, compared with rat hepatoma dRLh-84 cells, which are much more sensitive to t10, c12 CLA: less than 25 % viable cells persisted following treatment with 1 μM of this isomer.