The t10, c12 CLA isomer has been shown to inhibit growth and induce apoptosis in a number of cell lines, such as HT-29 human colon cancer cells (Cho et al., 2005, 2006), Caco-2 colon cancer cells (Kim et al., 2002b), human colorectal cancer (CRC) cells (Lee et al., 2006), dRLh-84 rat hepatoma cells (Yamasaki et al., 2005) and the PC-3 human prostatic carcinoma cell line (Ochoa et al., 2004), while similar effects have not been reported for the c9, t11 CLA isomer at the same concentrations. The gene discussed is SELPLG; the disease is colorectal cancer.