TFPI and Sepsis: Other studies have shown that active site-inhibited F VIIa (F VIIai) and TFPI reduce the expression of pro-inflammatory cytokines IL-6 and IL-8 in vivo, decrease coagulation and thereby prevent death in a lethal baboon model of Escherichia coli-induced sepsis (Creasey et al., 1993; Taylor et al., 1998).