Since TF expression is under the control of transcription factors such as nuclear factor κB (NFκB) (Guha et al., 2001), which is also activated by TLR2 (Roeder et al., 2004), it is tempting to speculate that tlr2 polymorphisms may influence the severity of coagulation disorders in invasive streptococcal infections. The gene discussed is TF; the disease is blood coagulation disease.