However in multiple regression analysis showed that the subjects who had urinary Cd levels greater than 5 μg/g of creatinine significantly influenced only the urinary total-N-acetyl-beta -D-glucosaminidase but not on isoenzymes A and B. Hence, urinary total-N-acetyl-beta -D-glucosaminidase activity could be used as biomarker for renal tubular dysfunction in Cd-exposed workers. Here, OGA is linked to renal tubule disorder.