Fondaparinux, a 1.7 kDa pentasaccharide which selectively binds ATIII, is approved for the prevention of venous thromboembolism following hip fracture surgery, total hip replacement, total knee replacement, and major abdominal surgery in addition to the initial treatment of patients with deep venous thrombosis and pulmonary embolism [42–47]. The gene discussed is SERPINC1; the disease is Venous thrombosis.