In contrast, TLR2-/-, TLR4-/-, and TLR2/4-/- animals displayed significantly (P<0.001) lower clinical scores of 7.1±1.6, 7.0±3, and 4.2±2.3, respectively, as compared to wt animals, thus indicating that colitis is exacerbated via TLR2- and TLR4-signaling (Figure 1A). The gene discussed is TLR4; the disease is colitis.