However, we observed a relatively high frequency (23%) of mutations in peripherin/RDS among autosomal dominant Spanish families with central retinal dystrophies (adMD), slightly higher than that seen in other studies of adMD (18% of AVMD) [20], and 7.3% of adMD in a British population [21]. Here, PRPH is linked to adult-onset foveomacular vitelliform dystrophy.