The possible sources of oxidative stress in diabetes might include autooxidation of glucose, shifts in redox balances, decreased tissue concentrations of lowmolecular weight antioxidants such as reduced glutathione (GSH)and vitamin E, and impaired activities of antioxidant defenseenzymes such as superoxide dismutase (SOD) and catalase[16, 31–33]. The gene discussed is CAT; the disease is diabetes mellitus.