NFKB1 and diabetes mellitus: We have shown that NF-kB is activated in endothelial cells and pericytes incubated in high glucose medium, and inretina in diabetes before either cell death or histopathology canbe seen, and this continues during the time when thehistopathology is developing, suggesting that the activation ofNF-kB is an early event in the development of diabeticretinopathy [19].