Activated PKC can bring about a variety of changes characteristic of diabetic retinopathy that include increasing vessel permeability, bloodflow, alteration of hormone and growth factor receptor recycling,stimulation of neovascularization, endothelial proliferation andapoptosis, and regulating the action of several factors such asVEGF, IGF-1, and transforming growth factor β[63–65]. This evidence concerns the gene IGF1 and diabetic retinopathy.