Interestingly, all the nine breast cancer patients found positive to BRCA2-8765delAG were from families with at least three affected members in first-degree relatives [whereas familial recurrence of breast cancer was observed in 87 (13.5%) out of 644 mutation-negative patients, whose information on family history for cancer was available], further confirming that occurrence of the BRCA2 mutations is strictly associated with the presence of a higher familial recurrence of the disease. The gene discussed is BRCA2; the disease is cancer.