BRCA2 and breast carcinoma: To evaluate the prevalence of BRCA2-8765delAG in breast cancer cases across the entire Sardinia, we screened genomic DNA obtained from both peripheral blood and paraffin-embedded normal tissues (see Methods) of 1,141 unselected and consecutively-collected BC patients originating from either the northern (N = 648) or southern (N = 493) part of the island.