BRCA1 and breast carcinoma: As we previously described [11-13], the prevalence of the BRCA2-8765delAG mutation in breast cancer families was lower than that of other BRCA1-2 founder mutations observed in different genetically-homogeneous populations (three BRCA1 and a single BRCA2 founder mutations account for vast majority of breast cancer families among Ashkenazi Jews [21] and Icelanders [22], respectively).