These findings are also supported by recent experiments using MIF-knockout mice in a p53-null background, which showed that MIF deficiency leads to a shift in the tumor spectrum: while the expected high frequency of T-cell lymphomas and fibrosarcomas was reduced upon MIF deficiency, the frequency of B-cell lymphomas and carcinomas was strongly increased. This evidence concerns the gene TP53 and B-cell non-Hodgkin lymphoma.