PINK1 and Alzheimer disease: Interestingly, PINK1 was absent from other protein-filled intracellular structures (called inclusions), such as cortical Lewy bodies, in neurofibrillary tangles in Alzheimer disease, in progressive supranuclear palsy and corticobasal degeneration, and in the glial and neuronal alpha-synuclein positive inclusions in multiple system atrophy [17].