Recenty, Kanazawa and colleagues [46] suggested that VEGF levels in induced sputum could be possibly used as a non-invasive marker of pulmonary vascular remodeling in patients with bronchitis type of COPD, indicating that VEGF may have a potential role in the pathogenesis of the vascular changes that take place in this group of patients. This evidence concerns the gene VEGFA and bronchial disorder.