DES and cardiomyopathy: In addition, prominent desmin accumulation in skeletal and cardiac muscle fibres from other patients with minicores on muscle biopsy and a primary cardiomyopathy [76] may point to primary involvement of the desmin (DES) or related genes; also, mutations in the lamin A/C (LMNA) gene, a common cause of various muscular dystrophy and cardiac phenotypes [for review, [77]], may also be associated with core-like structures on muscle biopsy and have to be considered in cases with minicores and prominent cardiac involvement.