The goal of the first experiment was to evaluate the effect of daily subcutaneous injection treatment with 1 mg/kg of prednisone, a glucocorticoid that has been shown to have efficacy at this dose in the mdx model and DMD patients [6,19,20], and a CRF2R agonist (PG-873637), either alone or in combination. Here, CRHR2 is linked to Duchenne muscular dystrophy.