The lower frequency of SFRP1 down-regulation than the previous report [22] could be ascribed to the heterogeneity of hepatocellular carcinoma due to etiology, ethnics, etc. Moreover, SFRP1 was found to be significantly decreased in 30 (30%) of 100 HCC specimens on tissue array at protein levels. The gene discussed is SFRP1; the disease is hepatocellular carcinoma.