Univariate analysis between the proportions of marker expression in the tumor cells and all other variables investigated showed tendencies to correlate between MDM2 and PCNA (p = 0.07) (Graph 5, Table 2); PCNA and p53 (p = 0.12) (Graph 5 and Tables 3 and 4); alkaline phosphatase index higher than 150 U and MDM2 (p = 0.09); and unfavorable histology and p53 (p = 0.15) (Tables 1, 2, 3 and 4), but there was no association of marker expression between MDM2 and p53 (p = 0.88 in the Kaplan-Meier test) (Graph 5 and Tables 3 and 4). The gene discussed is PCNA; the disease is neoplasm.