The Epstein-Barr virus (EBV) genome is found in up to 50% of cases of HD.22 EBNA-1 (Epstein-Barr nuclear antigen-1) bonds with p53 and it has been suggested that EBNA-1 expression results from that interaction.23 The exact role of EBV in HD genesis is not clear yet.22,23. This evidence concerns the gene TP53 and Huntington disease.