Wild-type p53 protein encoded by the p53 gene acts in the cell cycle to interrupt it at the G1 phase.13 This suppressive activity allows DNA repair in injured cells and avoids apoptosis.14 Deletion or mutation of p53 is classically associated with p53 tumor activity.13-15 Mutated p53 has a mean half-life of six to eight hours and no suppressive action, and it is easily detectable by immunohistochemistry methods. This evidence concerns the gene TP53 and neoplasm.