MTHFR C677T homozigosity was present in 15/20 patients with UFS and 17/20 patients with RPL compared to 3/20 subjects of control group (Table 1); differences were significant both for sterility and RPL when compared to control group (p: <0.01 UFS vs control group and RPL vs control group) (Table 2). Here, MTHFR is linked to infertility disorder.