It is well established that in both T and B cells, BCL10 specifically mediate antigen receptor-induced NF-κB activation [37] In NK cells, BCL10 has been observed in the cytoplasm of normal NK cells, and in the nuclei of tumor cells of nasal NK/T-cell lymphomas [50]. Here, NFKB1 is linked to T-cell non-Hodgkin lymphoma.