IGFBP3 and breast cancer: Among ovarian carcinomas, only a handful such genes have been shown to exhibit DNA promoter hypermethylation, including the Insulin-like growth factor binding protein-3 (IGFBP-3) [8], the Deleted in Lung and Esophageal Cancer 1 (DLEC1) [9], and the breast cancer gene BRCA1 [10].