Alternatively, NF-κB might be induced via EGFR-mediated pathways, since EGFR was found to be overexpressed in 30–50% of pancreatic adenocarcinomas (Korc et al, 1986), and EGFR activation was proposed to lead to NF-κB activation in cell lines (Habib et al, 2001). Here, NFKB1 is linked to pancreatic adenocarcinoma.