Consequently, NF-κB inhibition by transfection with a mutated IκBα leads to a repression of tumorigenic potential (Fujioka et al, 2003b), angiogenesis (Xiong et al, 2004) and metastatic potential (Fujioka et al, 2003a) of pancreatic adenocarcinoma cell lines in xenograft mouse models. The gene discussed is NFKB1; the disease is pancreatic adenocarcinoma.