ING1 and acute pancreatitis: However, the maximum tolerated dose of the high-affinity EpCAM-targeting mAb ING-1, as determined in a dose escalation study, turned out to be low, with only 0.1 mg kg−1i.v. Additionally, severe toxicity in the form of acute pancreatitis occurred at higher concentrations (de Bono et al, 2004).