Although the underlying molecular mechanisms that could explain this synergistic inhibitory effect on gallbladder cancer cell growth remain to be elucidated, it is possible that treatment with SST reduces the expression of high affinity SST receptors in gallbladder cancer cells, an effect of SST that has been demonstrated in pancreatic tumor cell lines [23], which may alter the landscape of receptors and other cell surface proteins on gallbladder cancer cells. The gene discussed is SST; the disease is gallbladder cancer.