In line with this, the most dramatic effect in general was seen when only the SA' site was mutated as shown for Akv-CD; the tumor incidence of this mutant with respect to splenic marginal zone lymphoma (SMZL) increased from 8% to 28% (p < 0.1) and decreased to 0% as shown for Akv-EH (p < 0.05) and for Akv-CDH (p = 0.5). This evidence concerns the gene CHDH and splenic marginal zone lymphoma.