Two other mouse models that carry different genetic alterations leading to colon tumor formation are based on the observation that transforming growth factor (TGF)β type II receptor (TGFBR2) gene mutations are present in up to 30% of sporadic CRCs and in more than 90% of tumors that occur in patients with the DNA mismatch repair deficiency associated with hereditary non-polyposis colon cancer (HNPCC) [12]. Here, TGFBR2 is linked to hereditary nonpolyposis colon cancer.