Moreover, combined activation of canonical WNT signaling and inhibition of TGFβ signaling also results in more advanced intestinal tumors in Apcdelta716/+; Smad4+/- mice [46], and intestine-specific deletion of the type II TGFβ receptor in Apc1638N/wt mice [47]. The gene discussed is TGFB1; the disease is intestinal neoplasm.