Moreover, consistent with the over-expression of Myc in tumors from the ApcMin/+ and AOM models, we detected enrichment of Myc targets, such as Apex, Eef1d, Eif2a, Eif4e, Hsp90, Mif, Mitf, Npm1 [20], and the repression of Nibam [20]. This evidence concerns the gene NPM1 and infectious otitis media.