Cell transformation (ESR1, SRC), basal membrane disruption (MMP7), cell extension (ATF3, CD82, IL6, SRC), contact growth inhibition (JUN, IL6), osteocyte differentiation (IL6, JUN, SMAD6, SRC), cell cycle progression (ESR1, IER3, IL6, PSEN2), ERK/MAPK signaling (ESR1, ETS2, PPP1R10, PPP2R5C), development of tumor (CXCL6, ESR1, IER3, IL6, JUN), invasion of colon cancer cell lines (CD82, SRC), colon cancer (JUN, PDGFRL, SRC). Here, ESR1 is linked to colonic neoplasm.