Two SNPs showed some evidence of an association with CRC risk: rs162558, which maps 5' to CYP1B1, and rs2069522, which maps 5' to CYP1A2. Homozygotes for rs162558 in CYP1B1 and heterozygotes for rs2069522 in CYP1A2 were associated with a mildly increased risk of CRC (OR = 1.36, 95% CI: 1.03–1.80 and OR = 1.34, 95% CI: 1.00–1.79 respectively), although neither of these findings were significant after correction for multiple testing (adjusted p = 1.0). The gene discussed is CYP1A2; the disease is colorectal carcinoma.